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The research delves into the molecular and cellular levels of these processes, including the role of neurotransmission, neuroinflammation, and epigenetic modifications (New Frontiers in Alcohol Withdrawal)

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Human MTHFR consists of an N-terminal catalytic domain (amino acids 1356) which binds 5,10-methylenetetrahydrofolate (5,10-methylene THF), and a C-terminal regulatory domain (amino acids 363656) which binds S-adenosylmethionine (AdoMet, SAM) 16,17